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Chase has been shown as ambitious, amoral, and sycophantic. These qualities appear to be either influenced or amplified by House. Dr. Chase’s angst supervisor seems also to inspire within him some manner of insecurity, as might be illustrated by the way in which Chase feeds information to Edward Vogler, a nemesis of House in several episodes, to ensure his job.

Chase has shown irreverence for patients similar to that of House in that past, (though he reserves his comments to areas away from the patients, unlike House who is forward with his views). Further, Chase seems to take joy in watching House tear into others. Chase is arguably both the oldest and the most creative member of House's staff. He often suggests unconventional treatments before others. His status as the oldest of House’s staff is hinted at in an episode where Chase describes details of previous work with House to Dr. Eric Foreman, citing himself as speaking to the doctor that was around before Dr. Allison Cameron.

Chase He slept with a drugged-up Cameron. Upon a personal level, Chase’s life has been gradually illustrated throughout the series. He seems to come from a wealthy Catholic Australian family. Further, in one episode Chase reveals to a patient that he attended a seminary school, quoting 1 Peter 1:7. Chase's father, who dies of cancer in the course of the series, is revealed to have left the family when Chase was young. This circumstance left Chase to contend with his alcoholic mother alone until her death.

Within a popular comparison which draws parallels between Dr. House and Sir Arthur Conan Doyle’s Sherlock Holmes, Chase takes on the role of one members of the Baker Street Irregulars, characters that might run odds tasks for Holmes in the course of his investigations to aid in uncovering truth.